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TFEB activator 1
CAS No. 39777-61-2
TFEB activator 1( (1E4E)-15-Bis(2-Methoxyphenyl)penta-1 | Curcumin analog C1 | Curcumin analog compound C1 | RPN77612 )
Catalog No. M21148 CAS No. 39777-61-2
TFEB activator 1 is an activator?of transcription factor EB (TFEB) ?with promise for the prevention or treatment of Alzheimer's disease.
TFEB activator 1 is an activator?of transcription factor EB (TFEB) ?with promise for the prevention or treatment of Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
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| 5MG | 51 | In Stock |
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| 10MG | 77 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 259 | In Stock |
|
| 100MG | 405 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTFEB activator 1
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NoteResearch use only, not for human use.
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Brief DescriptionTFEB activator 1 is an activator?of transcription factor EB (TFEB) ?with promise for the prevention or treatment of Alzheimer's disease.
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DescriptionTFEB activator 1 is an activator?of transcription factor EB (TFEB) ?with promise for the prevention or treatment of Alzheimer's disease.
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In VitroWestern Blot Analysis Cell Line:N2a cells Concentration:0, 0.2, 0.4, 0.6, 0.8 and 1 μM Incubation Time:12 hours Result:Treatment dose-dependently increased the levels of LC3-II and SQSTM1/p62 (sequestosome 1).
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In VivoAnimal Model:Adult male Sprague-Dawley (SD) rats weighing 350 to 400 gDosage:10 mg/kg and 25 mg/kg Administration:Short-term oral administration; for 24 hoursResult:Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain. Animal Model:Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g Dosage:10 mg/kg Administration:Chronic oral administration; daily; for 21 days Result:Activated TFEB and enhanced autophagy in rat brains.
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Synonyms(1E4E)-15-Bis(2-Methoxyphenyl)penta-1 | Curcumin analog C1 | Curcumin analog compound C1 | RPN77612
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PathwayOthers
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TargetOther Targets
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RecptorTFEB
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Research Area——
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Indication——
Chemical Information
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CAS Number39777-61-2
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Formula Weight294.34
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Molecular FormulaC19H18O3
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Purity>98% (HPLC)
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SolubilityDMSO:59 mg/mL (200.45 mM)Ethanol:2 mg/mL (6.79 mM)
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SMILESCOc1ccccc1/C=C/C(=O)/C=C/c1ccccc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Song JX et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89.
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